Immunostimulatory nucleic acid molecules

US6239116A · kind A · utility

Assignees

• University of Iowa Research Foundation · US
• COLEY PHARMACEUTICAL GMBH · DE
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Arthur M. Krieg · Wellesley, US
• Joel Kline · Iowa City, US

Key dates

• Filing date: Oct 30, 1997
• Grant date: May 29, 2001
• Expiry date: Oct 30, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.