Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds

US6251909A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Gerd Schnorrenberg · Ingelheim am Rhein, DE
• Horst Dollinger · Schemmerhofen, DE
• Franz Esser · Ingelheim am Rhein, DE
• Hans Briem · Bremen, DE
• Birgit Jung · Laupheim, DE
• Georg Speck · Ingelheim am Rhein, DE

Key dates

• Filing date: Feb 18, 2000
• Grant date: Jun 26, 2001
• Expiry date: Feb 18, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein PA1 R.sup.1 and R.sup.2 together with the N to which they are bound form a ring of the formula ##STR2## PA1 wherein PA2 p is 2 or 3 and PA2 X denotes oxygen, N(CH.sub.2).sub.n R.sup.6 or CR.sup.7 R.sup.8, PA1 and R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.