Carbamate-based cationic lipids
US6251939A · kind A · utility
46Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1996 |
| Grant date | Jun 26, 2001 |
| Priority date | — |
| Expiry date | Jun 5, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0205
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel carbamate-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof, wherein (a) R.sub.1 is a lipophilic moiety; (b) R.sub.2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions, and a kit for preparing the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.