Inventor · Littleton, MA, US

Bob D. Brown

94Patents
14h-index
28Co-inventors
84Inventor score

Filing activity: Nov 21, 1994 → Aug 16, 2024

Most-cited inventions

PatentTitleAreaCited byStatus
US8513207B2 Extended dicer substrate agents and methods for the specific inhibition of gene expression Chemistry; Metallurgy 91 Active
US8349809B2 Single stranded extended dicer substrate agents and methods for the specific inhibition of gene expression Chemistry; Metallurgy 85 Active
US6020526A Amide-based cationic lipids Chemistry; Metallurgy 52 Expired
US6034135A Dimeric cationic lipids Human Necessities 51 Expired
US5877220A Amide-based oligomeric cationic lipids Chemistry; Metallurgy 51 Expired
US6172049A Phosphonic acid-based cationic lipids Chemistry; Metallurgy 50 Expired
US5958901A Phosphonic acid-based cationic lipids Chemistry; Metallurgy 50 Expired
US6251939A Carbamate-based cationic lipids Chemistry; Metallurgy 46 Expired
US6339173B1 Amide-based cationic lipids Chemistry; Metallurgy 41 Expired
US6638529B2 Amide-based cationic lipids Chemistry; Metallurgy 39 Expired
US6028188A Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages Human Necessities 25 Expired
US8927705B2 Single stranded extended dicer substrate agents and methods for the specific inhibition of gene expression Chemistry; Metallurgy 23 Active
US10144725B2 Amine cationic lipids and uses thereof Chemistry; Metallurgy 18 Active
US9458457B2 Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Chemistry; Metallurgy 16 Active
US10370655B2 Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Chemistry; Metallurgy 13 Active
US9701966B2 Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA Chemistry; Metallurgy 11 Active
US6670393B2 Carbamate-based cationic lipids Chemistry; Metallurgy 11 Expired
US8679789B2 Oligonucleotides comprising a molecular switch Chemistry; Metallurgy 8 Active
US8372816B2 Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA Chemistry; Metallurgy 7 Active
US8815825B2 Methods and compositions for the specific inhibition of beta-catenin by double-stranded RNA Chemistry; Metallurgy 6 Active
US9828606B2 Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA Chemistry; Metallurgy 5 Active
US10351854B2 Therapeutic inhibition of lactate dehydrogenase and agents therefor Emerging Cross-Sectional Technologies 5 Active
US10150965B2 Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA Chemistry; Metallurgy 5 Active
US8927515B2 Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA Chemistry; Metallurgy 5 Active
US9732347B2 Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA Chemistry; Metallurgy 4 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.