Product of infectious respiratory syncytial virus from cloned nucleotide sequences
US6264957A · kind A · utility
37Cited by
2References
22Claims
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Key dates
| Filing date | Sep 27, 1996 |
| Grant date | Jul 24, 2001 |
| Priority date | — |
| Expiry date | Sep 27, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18543
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Isolated polynucleotide molecules provide RSV genome and antigenomes, including that of human, bovine or murine RSV or RSV-like viruses, and chimera thereof. The recombinant genome or antigenome can be expressed with a nucleocapsid (N) protein, a nucleocapsid phosphoprotein (P), a large (L) polymerase protein, and an RNA polymerase elongation factor to produce isolated infectious RSV particles. The recombinant RSV genome and antigenome can be modified to produce desired phenotypic changes, such as attenuated viruses for vaccine use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.