Method of identifying inhibitors of the Jak-Stat signal transduction pathway
US6265160A · kind A · utility
20Cited by
4References
20Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 7, 1998 |
| Grant date | Jul 24, 2001 |
| Priority date | — |
| Expiry date | Jan 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Agents which inhibit the Jak-Stat signal transduction pathway are identified in order to identify candidate drugs for treatment of proliferative disorders. Identification methods are alternatively based on inhibiting the interaction of: (1) the activated Stat3 and Stat5 transcription factors with an electrophoretic mobility shift assay probe, or (2) the Stat3 or Stat5 proteins with the IL-2R.beta. chain of the IL-2 receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.