1H-pyrido[2,3-b][1,5]benzodiazipine vasopressin agonists
US6268360A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2000 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Oct 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of the general formula: ##STR1## wherein Y is a moiety selected independently, from NH or --(CH.sub.2).sub.n -- wherein n is 1; m is an integer from 1 to 2; and the moiety ##STR2## represents: (1) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is nitrogen, and B and C are CH), (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is carbon, B is nitrogen, and C is --CH--CH--), (3) a 6-membered aromatic (unsaturated) ring (wherein A is carbon, B is CH, and C is --CH--CH--); as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.