Amino anthracyclinone derivatives and their use in the treatment of amyloidosis
US6268362A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2000 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Sep 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/70
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (1), wherein R.sub.1 represents hydrogen, hydroxy, a group of formula OR.sub.7, wherein R.sub.7 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl; R.sub.2 represents hydrogen, hydroxy, diethylamino, piperidino, tetrahydropyridino or morpholino, and either R.sub.3, taken alone, represtnts hydrogen or hydroxy, and R.sub.4 and R.sub.5, taken alone, independently represent hydrogen, hydroxy or, taken together with the carbon atom, represent a carbonyl group; or R.sub.3 and R.sub.4, taken together, represent a group of formula (A), wherein R.sub.8 and R.sub.9 represent a C.sub.1 -C.sub.6 alkyl and R.sub.5 represents hydrogen; R.sub.6 represents hydrogen or a phenyl group, optionally substituted by methyl, methoxy or halogen and the pharnaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.