10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition

US6268375A · kind A · utility

Assignees

• Research Triangle Institute · US
• Bristol-Myers Squibb Company · US

Inventors

• Monroe E. Wall · Chapel Hill, US
• Mansukh C. Wani · Durham, US
• Govindarajan Manikumar · Raleigh, US
• Neelakantan Balasubramanian · Madison, US
• Dolatrai M. Vyas · Fayetteville, US

Key dates

• Filing date: Dec 29, 1999
• Grant date: Jul 31, 2001
• Expiry date: Dec 29, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Camptothecin compounds having a C.sub.10 11 O--(CF.sub.2).sub.n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.