Fatty-acid amide hydrolase
US6271015A · kind A · utility
61Cited by
1References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1996 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Nov 4, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/6418
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary(amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a compound without soporific activity. FAAH has be isolated and the gene encoding FAAH has been cloned, sequenced, and used to express recombinant FAAH. Inhibitors of FAAH are disclosed to block the hydrolase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.