Camptothecin .beta.-alanine esters with topoisomerase I inhibition
US6288072A · kind A · utility
4Cited by
20References
8Claims
0Family size
Inventors
Key dates
| Filing date | Dec 29, 1999 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Dec 29, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
.beta.-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.