N-substituted 4-(4'-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties

US6291481A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jean-Paul René Marie André Bosmans · Rijkevorsel, BE
• Christopher John Love · Deurne, BE
• Marc Gustaaf Celine Verdonck · Lille, BE
• Joannes Adrianus Jacobus Schuurkes · Beerse, BE

Key dates

• Filing date: Aug 27, 1998
• Grant date: Sep 18, 2001
• Expiry date: Aug 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the substituents are as described in the specification, and process for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.