Process and intermediates useful to produce vitamin D analogs
US6291694A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2000 |
| Grant date | Sep 18, 2001 |
| Priority date | — |
| Expiry date | Aug 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1892
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A stereospecific method for accomplishing the below reaction: ##STR1## results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R.sup.1 is C.sub.1 -C.sub.6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pK.sub.a less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.