Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

US6307089A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Claude Forsey Purchase, Jr. · Ann Arbor, US
• Bruce D. Roth · Ann Arbor, US
• Gerald Paul Schielke · Ann Arbor, US
• Lary Craswell Walker · Ann Arbor, US
• Andrew White · Ann Arbor, US

Key dates

• Filing date: Dec 14, 2000
• Grant date: Oct 23, 2001
• Expiry date: Dec 14, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells.