Acylated oligopeptide derivatives having cell signal inhibiting activity

US6307090A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Terrence R. Burke, Jr. · Kirkwood, US
• Zhu-jun Yao · Shanghai, CN
• C. Richter King · Washington, US

Key dates

• Filing date: Jan 22, 1999
• Grant date: Oct 23, 2001
• Expiry date: Jan 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an acylated peptide, namely a compound of formula (I), ##STR1## wherein PA1 n is 0 to 15, PA1 X is oxalyl PA1 PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimetic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is secondary amino group, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.