Antibodies against human CD40

US6312693A · kind A · utility

Inventors

• Alejandro A. Aruffo · Edmonds, US
• Diane Hollenbaugh · Seattle, US
• Anthony W. Siadak · Seattle, US
• Karen K. Berry · Princeton, US
• Linda Harris · Greely, CA
• Barbara A. Thorne · Issaquah, US
• Jurgen Bajorath · Bainbridge Island, US
• William D. Huse · Del Mar, US
• Herren Wu · Boyds, US
• Jeffry D. Watkins · Encinitas, US

Key dates

• Filing date: Feb 10, 1999
• Grant date: Nov 6, 2001
• Expiry date: Feb 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The Applicants have discovered humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.