Neurite outgrowth-promoting polypeptides containing fibronectin type III repeats and methods of use
US6313265A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 24, 1995 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | Jul 24, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides that promote neurite outgrowth. The polypeptides contain fibronectin Type III repeats derived from a family of cell adhesion molecules characterized by having 6 immunoglobulin domains and 5 fibronectin Type III repeats. The polypeptides of this invention correspond to F80, 3-5 and 4-5 regions of the cell adhesion family members chicken Ng-CAM, chicken Nr-CAM, mouse L1CAM, human L1CAM and homologs thereof. Methods of promoting neurite outgrowth in both diagnostic and therapeutic applications are also described as are methods of making the disclosed polypeptides and devices for using thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.