Oligonucleotides which specifically bind retroviral nucleocapsid proteins

US6316190A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Alan Rein · Takoma Park, US
• Jose Casas-Finet · Gaithersburg, US
• Robert A. Fisher · Mesa, US
• Matthew Fivash · Frederick, US
• Louis E. Henderson · Mount Airy, US

Key dates

• Filing date: Jul 12, 1999
• Grant date: Nov 13, 2001
• Expiry date: Jul 12, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides oligonucleotides which bind to retroviral nucleocapsid proteins with high affinity, molecular decoys for retroviral nucleocapsid proteins which inhibit viral replication, targeted molecules comprising high affinity oligonucleotides, assays for selecting test compounds, and related kits.