Sulfonamide interleukin-1.beta. converting enzyme inhibitors

US6316415A · kind A · utility

Assignees

• BASF SE
• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Hans P. Albrecht · Weinheim, DE
• Hamish Allen · Boylston, US
• Kenneth Dale Brady · Worcester, US
• William Harter · Chelsea, US
• Catherine R. Kostlan · Saline, US
• Bruce D. Roth · Ann Arbor, US
• Nigel Pelham Clinton Walker · Burlingame, US

Key dates

• Filing date: Apr 9, 1999
• Grant date: Nov 13, 2001
• Expiry date: Apr 9, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme. ##STR1##