Small molecule chloride transport
US6323191A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1999 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Jun 17, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride (Cl.sup.-) channel regulated by phosphorylation and intracellular nucleotides. CFTR is the major Cl.sup.- transport pathway in airway epithelial cells. The abnormal transepithelial Cl.sup.- transport and subsequent defective fluid transport caused by CF is a result of the genetic mutations of the gene coding for the CFTR protein. The present invention is directed to the novel use of ionophores as artificial Cl.sup.- transport pathways into CF epithelia to treat the defective Cl.sup.- and fluid transport lonophores and in particular, small molecule ionophores, represent a potential novel means of treating CF. The invention also includes using an ionophore to generate chloride secretion on intact monolayers of airway epithelia cells and other epithelia cells by administering an ionophore to a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.