Aldol condensations by catalytic antibodies

US6326176A · kind A · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Carlos F. Barbas, III · Solana Beach, US
• Richard A. Lerner · Village of La Jolla, US
• Guofu Zhong · San Diego, US
• Benjamin List · Wetter (Ruhr), DE

Key dates

• Filing date: May 18, 2000
• Grant date: Dec 4, 2001
• Expiry date: May 18, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0002
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.