Intermediates for oligonucleotide synthesis
US6329519A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 15, 1999 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Mar 15, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (I) wherein B.sup.1 is a radical of a nucleoside base, R.sup.1 is hydrogen or a hydroxy-protecting group, R.sup.2 is hydrogen, hydroxy or a 2'-nucleoside-modifying atom or group, R.sup.3 is an unsubstituted or substituted C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.4 to C.sub.10 cycloalkylalkyl, C.sub.6 to C.sub.10 aryl or C.sub.7 to C.sub.13 aralkyl group, and Z is halogen or a group of formula (II) where R.sup.4 and R.sup.5 are each independently an unsubstituted or substituted C.sub.1 to C.sub.10 alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.4 to C.sub.10 cycloalkylalkyl, C.sub.6 to C.sub.10 aryl or C.sub.7 to C.sub.13 aralkyl group, or R.sup.4 is said group and R.sup.5 is hydrogen or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O--, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5'-methylene thereof to the indicated oxygen atom. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.