Protein tyrosine kinase agonist antibodies

US6331302A · kind A · utility

Assignee

• Genentech, Inc. · US

Inventors

• Brian D. Bennett · Thousand Oaks, US
• David V. Goeddel · Hillsborough, US
• James Lee · Dongguan, CN
• William Matthews · West Chester, US
• Siao-Ping Tsai · South San Francisco, US
• William I. Wood · Hillsborough, US

Key dates

• Filing date: May 23, 1996
• Grant date: Dec 18, 2001
• Expiry date: May 23, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.