Cell-cycle regulatory proteins, and uses related thereto
US6331390A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 30, 1995 |
| Grant date | Dec 18, 2001 |
| Priority date | — |
| Expiry date | Jun 30, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4739
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins ("CCR-proteins"). As described herein, this family of proteins is characterized by four ankyrin repeats and the ability to bind to a cyclin dependent kinase (CDK). The family includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.