Nucleic acid ligands
US6331398A · kind A · utility
38Cited by
12References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 10, 2000 |
| Grant date | Dec 18, 2001 |
| Priority date | — |
| Expiry date | Feb 10, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention comprises nucleic acid ligand for use as a diagnostic reagent for detecting the presence or absence of a target molecule in a sample, and a diagnostic reagent to measure the amount of a target molecule in a sample. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified by further partitioning.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.