Compositions of solvents and high concentrations of nucleic acid analogs
US6331618A · kind A · utility
12Cited by
5References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 13, 1999 |
| Grant date | Dec 18, 2001 |
| Priority date | — |
| Expiry date | May 13, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6806
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analogs such as PNA can be achieved in the range of approximately 1 .mu.M to 10 mM.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.