Agents that bind to and inhibit human cytochrome P450 1A2

US6335428B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Harry V. Gelboin · Bethesda, US
• Frank J. Gonzalez · Bethesda, US
• Tian Yang

Key dates

• Filing date: Apr 8, 1999
• Grant date: Jan 1, 2002
• Expiry date: Apr 8, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/968
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 1A2 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 1A2 and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 1A2, and in methods of measuring p450 1A2 levels in individuals relative to p450 1A2 levels in a control population.