Modified aminoacids, pharmaceuticals containing these compounds and method for their production

US6344449B1 · kind B1 · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Klaus Rudolf · Warthausen, DE
• Wolfgang Eberlein · Biberach, DE
• Wolfhard Engel
• Helmut Pieper · Lohr am Main, DE
• Henri Doods · Warthausen, DE
• Gerhard Hallermayer · Biberach an der Riß, DE
• Michael Entzeroth · Warthausen, DE
• Wolfgang Wienen · Äpfingen, DE

Key dates

• Filing date: Oct 12, 1999
• Grant date: Feb 5, 2002
• Expiry date: Oct 12, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to modified amino acids of general formula whereinA, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.