4-[3-benzofuranyl]piperidinyl and 4-[3-benzothienyl]piperidinyl derivatives

US6348457B1 · kind B1 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jan Vandenberk · Beerse, BE
• Ludo Edmond Josephine Kennis · Lier, BE
• Albertus Henricus Maria Theresia Van Heertum · Turnhout, BE

Key dates

• Filing date: Jan 5, 1995
• Grant date: Feb 19, 2002
• Expiry date: Jan 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, whereinX is oxygen or sulphur; R1 is hydrogen or halo; R2 is hydrogen, C1-4alkyl, phenylmethyl or halophenylmethyl; Alk is C1-4alkanediyl; —Z—A— is a bivalent radical selected from the group consisting of —S—CH2—CH2, —S—CH2—CH2—CH2—, —S—CH═CH—, —CH═CH—CH═CH—, —C(═CHR3)—CH2—CH2—CH2—, —CH═CH—O—, —CHR4—CH2—CH2—, —CHR4—CH2—CH2—CH2—, —CHR4—CH2—CH2—CH2—CH2—; in said bivalent radicals one hydrogen may be replaced by C1-4alkyl; R3 is phenyl or halophenyl; each R4 independently represents hydrogen, hydroxy, phenylmethyl or halophenylmethyl. Pharmaceutical compositions of said compounds and use as a medicine.