Antibodies with increased binding affinity
US6350861B1 · kind B1 · utility
316Cited by
5References
16Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | May 23, 1997 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | May 23, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/2896
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region and thereby modifies the affinity of the immunoglobulin for a preselected antigen. The methods and compositions of the invention provide immunoglobulins that possess increased affinity for antigen. Such glycosylation-altered immunoglobulins are suitable for diagnostic and therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.