Synthesis, deprotection, analysis and purification of RNA and ribozymes
US6353098B1 · kind B1 · utility
47Cited by
10References
22Claims
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Key dates
| Filing date | Jun 17, 1998 |
| Grant date | Mar 5, 2002 |
| Priority date | — |
| Expiry date | Jun 17, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for deprotecting RNA alkylsilyl groups comprising, contacting the groups with a solution of anhydrous triethylamine-hydrogen fluoride (aHF-TEA) in triethylamine and N-methylpyrrolidine at between 60° C.-70° C. for 0.25-24 h.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.