Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof
US6355256B1 · kind B1 · utility
3Cited by
1References
10Claims
0Family size
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Key dates
| Filing date | Mar 22, 1995 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | Mar 22, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55577
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention involves the combination of Interleukin-12 with p53 derived peptides and an adjuvant, preferably QS-21. It is found that this combination provokes a surprisingly strong immune response. Further, in an accepted in vivo model, the use of compositions containing these three ingredients led to diamatic decreases in the growth of induced tumors, thus suggesting a therapeutic regime.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.