Substituted 1-oxo- and 1,3-dioxoisoindoline and method of reducing inflammatory cytokine levels
US6380239B1 · kind B1 · utility
125Cited by
6References
18Claims
0Family size
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Key dates
| Filing date | Mar 17, 2000 |
| Grant date | Apr 30, 2002 |
| Priority date | — |
| Expiry date | Mar 17, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF&agr; in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.