Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use

US6387389B1 · kind B1 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Richard B. Rothman · Baltimore, US
• Kenner C. Rice · Bethesda, US
• David Malcolm Lewis · Toronto, CA
• Dorota Matecka · Washington, US
• John R. Glowa · Shreveport, US

Key dates

• Filing date: Jun 30, 1999
• Grant date: May 14, 2002
• Expiry date: Jun 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-release derivatives to bind the dopamine transporter to achieve a desired effect, such as antagonism of dopamine reuptake inhibitors, such as cocaine, or dopamine releasers or norepinephrine and/or serotonin reuptake inhibitors, such as methamphetamine.