Heregulin variants
US6387638B1 · kind B1 · utility
25Cited by
4References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 1998 |
| Grant date | May 14, 2002 |
| Priority date | — |
| Expiry date | Jul 17, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/485
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-&bgr;1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.