3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists

US6387885B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Christopher R. Dalton · Mundelein, US
• Milan Bruncko · Libertyville, US
• Michele A. Kaminski · Beach Park, US
• Lisa M. Frey · Mundelein, US
• Daryl Sauer · Pleasant Prairie, US
• Fortuna Haviv · Rehovot, IL

Key dates

• Filing date: Aug 26, 1998
• Grant date: May 14, 2002
• Expiry date: Aug 26, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.