Patent · US Expired

2,4,4-trisubstituted-1,3-dioxolane antifungals

US6387906B1 · kind B1 · utility

1Cited by

0References

14Claims

0Family size

Inventors

Lieven Meerpoel · Beerse, BE
Jan Heeres · Vosselaar, BE
Frank Christopher Odds · Schilde, BE
Hugo Florent Adolf Vanden Bossche · Beerse, BE
Louis Jozef Elisabeth Van Der Veken · Vosselaar, BE

Key dates

Filing date	Jan 7, 2000
Grant date	May 14, 2002
Priority date	—
Expiry date	Jan 7, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D233/56
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or 3; X is N or CH;each R1 independently is halo, nitro, cyano, amino, hydroxy, C1-4alkyl, C1-4alkyloxy or trifluoromethyl; R2 is hydrogen; C3-7alkenyl; C3-7alkynyl, aryl; C3-7cycloalkyl; optionally substituted C1-6alkyl R3 and R4 each independently are hydrogen, C1-6alkyl, C3-7cycloalkyl or aryl; or R3 and R4 taken together form a bivalent radical —R3—R4— of formula: wherein R5a, R5b, R5c, R5d each independently are hydrogen, C1-6alkyl or aryl; and aryl is optionally substituted phenyl; as antifungals; their preparation, compositions containing them and their use as a medicine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.