Reagent useful for synthesizing sulfurized oligonucleotide analogs
US6399831B1 · kind B1 · utility
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6Claims
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Key dates
| Filing date | Dec 1, 1999 |
| Grant date | Jun 4, 2002 |
| Priority date | — |
| Expiry date | Dec 1, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C329/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.