Antitumor composition containing a synergistic combination of an anthracycline derivative with a camptothecin derivate

US6403563B1 · kind B1 · utility

Assignee

• Pharmacia & Upjohn S.p.A. · IT

Inventors

• Cristina Geroni · Milano, IT
• Marina Ripamonti · Milano, IT
• Michele Caruso · Milano, IT
• Antonino Suarato · Milano, IT

Key dates

• Filing date: Sep 20, 2000
• Grant date: Jun 11, 2002
• Expiry date: Sep 20, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The combination of 4-demethoxy-3′-deamino-3′-aziridinyl-4′-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4′-methansulfonyl daunorubicin together with an antineoplastic topoisomerase I inhibitor yields preparations exhibiting anti-cancer effects. These preparations can be used in the treatment of tumors and especially 4-demethoxy-3′-deamino-3′-aziridinyl-4′-methansulfonyl daunorubicin in the treatment of brain tumors.