Method for increasing the serum half-life of a biologically active molecule
US6423685B1 · kind B1 · utility
111Cited by
4References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1999 |
| Grant date | Jul 23, 2002 |
| Priority date | — |
| Expiry date | Mar 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.