Defective recombinant adenovirus lacking E1A coding sequence and comprising a heterologous nucleotide sequence under control of the E1A promoter
US6426216B1 · kind B1 · utility
4Cited by
0References
16Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 2, 1995 |
| Grant date | Jul 30, 2002 |
| Priority date | — |
| Expiry date | Jun 2, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2730/10134
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant DNA modified by a nucleotide sequence coding for a specific polypeptide sequence whose expression is sought, this recombinant DNA being appropriate to the transformation of eucaryotic cell lines, notably human or animal, the endogenous polymerases of which are susceptible of recognizing the adenovirus promoters. The DNA according to the invention is more particularly characterized by the fact that the said insertion nucleotide sequence is placed under the direct control of the early promoter of the E1A region of the genome of adenovirus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.