3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

US6437138B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Nan-Horng Lin · Mundelein, US
• Yun He · Zion, US
• Mark W. Holladay · San Diego, US
• Keith B. Ryther · Round Lake Park, US
• Yihong Li · Millbrae, US
• Hao Bai · San Diego, US

Key dates

• Filing date: Mar 1, 2000
• Grant date: Aug 20, 2002
• Expiry date: Mar 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula I with the variables defined in the specification are also described.