Mitogen-activated protein kinase P38-2 and methods of use therefor
US6444455B1 · kind B1 · utility
1Cited by
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11Claims
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Key dates
| Filing date | Apr 20, 1999 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | Apr 20, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.