Antisense compositions for detecting and inhibiting telomerase reverse transcriptase

US6444650B1 · kind B1 · utility

Assignees

• Geron Corporation · US
• The Regents of the University of Technology Office of Technology Transfer · US

Inventors

• Thomas R. Cech · Frederick, US
• Joachim Lingner · Épalinges, CH
• Toru Nakamura · Boulder, US
• Karen B. Chapman · Sausalito, US
• Gregg B. Morin · Davis, US
• Calvin B. Harley · Palo Alto, US
• William H. Andrews · Reno, US

Key dates

• Filing date: Mar 31, 1998
• Grant date: Sep 3, 2002
• Expiry date: Mar 31, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/315
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.