Phosphate linked oligomers formed of monomeric diols and processes for preparing same

US6448373B1 · kind B1 · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Phillip Dan Cook · Carlsbad, US
• Oscar L. Acevedo · San Diego, US
• Peter Davis · Carlsbad, US
• David J. Ecker · Encinitas, US
• Normand Herbert · San Marcos, US

Key dates

• Filing date: Jan 11, 1994
• Grant date: Sep 10, 2002
• Expiry date: Jan 11, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/11
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.