Retinal pigmented epithelium derived neurotrophic factor and methods of use

US6451763B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Joyce Tombran-Tink · Parkville, US
• Gerald Chader · Bethesda, US
• Sofia Patricia Becerra · Bethesda, US
• Ignacio R. Rodriguez · Rockville, US
• Fintan R. Steele · Washington, US
• Lincoln V. Johnson · Lompoc, US

Key dates

• Filing date: Aug 29, 1995
• Grant date: Sep 17, 2002
• Expiry date: Aug 29, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor. The present invention also relates to a recombinant DNA molecule comprising a gene encoding a retinal pigmented epithelium derived neurotrophic factor having the DNA sequence or the amino acid sequence in SEQ ID NO:1 and to an organism transformed with the recombinant DNA molecule.In addition, the present invention relates to a method of treating tumors, ocular diseases, nerve injuries, and conditions resulting from the activity of serine proteases, which comprises administering PEDF.