Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods

US6451995B1 · kind B1 · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Nai-Kong V. Cheung · New York, US
• Steven M. Larson · New York, US
• Hong-Fen Guo · New York, US
• Ken Rivlin · New York, US
• Michel Sadelain · New York, US

Key dates

• Filing date: Sep 18, 1998
• Grant date: Sep 17, 2002
• Expiry date: Sep 18, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant antibody constructs comprise the variable regions of the heavy and light chains of anti-GD2 antibodies. These antibody constructs may be coupled to a label such as a radiolabel or to a protein such as streptavidin or pro-drug converting enzymes for use in imaging or therapeutic applications. The antibody constructs may also be transduced into T cells to produce populations of T cells which target GD2-producing tumor cells.