Carbamic acid derivatives

US6462198B1 · kind B1 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Konrad Bleicher · Glückstadt, DE
• Vincent Mutel · Mulhouse, FR
• Eric Vieira · Frenkendorf, CH
• Jurgen Wichmann · Steinen, DE
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: Apr 10, 2000
• Grant date: Oct 8, 2002
• Expiry date: Apr 10, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula whereinR1 signifies hydrogen or lower alkyl;R2, R2′ signify, independently from each other, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl;X signifies O, S or two hydrogen atoms not forming a bridge;A1/A2 signify, independently from each other, phenyl or a 6-membered heterocycle containing 1 or 2 nitrogen atoms;B is a group of formula  whereinR3 signifies lower alkyl, lower alkenyl, lower alkinyl, benzyl, lower alkyl-cycloalkyl, lower alkyl-cyano, lower alkyl-pyridinyl, lower alkyl-lower alkoxy-phenyl, lower alkyl-phenyl, which is optionally substituted by lower alkoxy, or phenyl, which is optionally substituted by lower alkoxy, or lower alkyl-thienyl, cycloalkyl, lower alkyl-trifluoromethyl or lower alkyl-morpholinyl,Y signifies —O—, —S— or a bond;Z signifies —O— or —S—;or B is a 5-membered heterocyclic group of formulas  whereinR4 and R5 signifies hydrogen, lower alkyl, lower alkoxy, cyclohexyl, lower alkyl-cyclohexyl or trifluoromethyl, with the proviso that at least one of R4 or R5 has to be hydrogen; as well as to their pharmaceutically accep…