Serine protease inhibitors

US6472393B1 · kind B1 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Ignacio Aliagas-Martin · San Francisco, US
• Dean R. Artis · Kensington, US
• Michael S. DINA · Daly City, US
• John A. Flygare · Burlingame, US
• Richard Goldsmith · Belmont, US
• Regina Munroe · San Mateo, US
• Alan G. Olivero · South San Francisco, US
• Richard Pastor · South San Francisco, US
• Thomas E. Rawson · Mountain View, US
• Kirk Robarge · San Francisco, US
• Daniel P. Sutherlin · Redwood City, US
• Kenneth Weese · South San Francisco, US
• Aihe Zhou · San Jose, US
• Yan Zhu · Beijing, CN

Key dates

• Filing date: Mar 21, 2000
• Grant date: Oct 29, 2002
• Expiry date: Mar 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C311/51
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.