Polynucleotides encoding human FRP and fragments thereof
US6479255B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 29, 1998 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | May 29, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2217/05
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.